The second edition of the Encyclopedia of Toxicology continues its comprehensive survey of toxicology. This new edition continues to present entries devoted to key concepts and specific chemicals. Found inside – Page 213The vasodilators nitroprusside and nitroglycerin are frequently used for controlled ... Cyanide toxicity results when this metabolism is overwhelmed. Found inside – Page 75Should evidence of acidosis occur , antidotal treatment for cyanide toxicity may be required ( 16 , 17 ) . Another ... Differential effects of nitroprusside , phentolamine , and nitroglycerin on cardiac function and peripheral circulation . Circ Res . Found insideWildlife Toxicity Assessments for Chemicals of Military Concern is a compendium of chemical-specific toxicity information with discussions on the rationale and development of Wildlife Toxicity Reference Values (TRVs) intended for use on ... Found inside – Page 203Treatment of cyanide toxicity is with sodium thiosul- fate (150 mg/kg IV in 50 mL ... Unlike nitroprusside, nitroglycerin poses no risk of cyanide toxicity. Found inside – Page 889Cyanide toxicity may be manifested as abdominal pain, confusion, or seizure and is ... Nitroglycerin, like nitroprusside, is a potent vasodilator; however, ... Found inside – Page 302The most common agents used for this purpose are nitroglycerin, sodium nitroprusside, ... However, to avoid the adverse effects of cyanide toxicity, ... Found insideVasodilator therapywith intravenous sodiumnitroprusside, nitroglycerin,or nesiritide may play a ... The majorlimitationofnitroprusside is cyanide toxicity. Found inside – Page 406Nitroglycerin can be helpful in the initial management of acute coronary ... If the patient is experiencing signs and symptoms of cyanide toxicity, ... Found inside – Page 530NITROGLYCERIN Intravenous nitroglycerin for hypertensive emergency has found ... Nitroprusside Metabolism and Cyanide Toxicity The principal steps of ... Found inside – Page 828Cyanide toxicity may be more subtle in onset and can be manifested by a decline in cardiac output that may follow an ... DILATRATE), intravenous nitroglycerin, and nitroglycerin ointment, sublingual tablets, and lingual spray, are relatively safe ... Found inside – Page 124High - dose nitroglycerin may result in heparin resistance . Nitroprusside is associated with cyanide toxicity , particularly at higher doses over prolonged ... Found inside – Page 193Patients with cyanide toxicity exhibit a metabolic acidosis in spite of ... of nitroglycerin is thought to be the same as described for nitroprusside. Found inside – Page 199Treatment of cyanide toxicity consists of discontinuing the sodium nitroprusside ... A new prodrug, sulfanegen sodium, is also being tested.80 Nitroglycerin ... Found inside – Page 249Thiosulfate binds cyanide and reduces the risk of cyanide toxicity (23), ... NITROGLYCERIN: Nitroglycerin is a “nitric oxide” vasodilator like nitroprusside ... Found inside – Page 79... avoid in hepatic or renal failure ; large doses may cause cyanide toxicity , drug tolerance Nitroglycerin ointments Prazosin Predominantly venous but some arteriolar vasodilation a - Receptor blockage ; arteriolar and venous dilation 1 - 3 mg ... Found insideSigns of cyanide toxicity include metabolic acidosis, arrhythmias, ... Action. Nitroglycerin causes smooth muscle relaxation and venous dilation by increasing. Found inside – Page 1220Cyanide intoxication has been reported when high concentrations of sodium nitroprusside were used , particularly in ... Brownish discoloration of the solution indicates degradation , whereupon replacement is in order . nitroglycerin is minimal . Found inside – Page 445Nitroglycerin Nitroglycerin (Nitrostat IV, Nitro-Bid IV, Tridil) relaxes ... developing metabolic acidosis, which may be an early sign of cyanide toxicity. Found inside – Page 343It may cause fetal cyanide toxicity and is therefore generally used on a short - term basis in pregnant women . g . Nitroglycerin ( 1 ) Nitroglycerin is a rapid - acting vasodilator and is used to treat angina or severe hypertension ( 20 ) . There are ... Found inside – Page 149... response to nitroglycerin • Onset of hypotensive effect • Larger doses of ... resistance and an 1 sv of thiocyanate and cyanide toxicity • Both preload ... Found inside – Page 1251... concurrent i.v. nitroglycerin Exaggerates hypotensive effects of nitrates ... both methemoglobinemia and potentially lethal cyanide toxicity when given ... Found inside – Page 149Cyanide toxicity has been documented to result in “unexplained cardiac ... Nitroglycerin is a potent venodilator but ineffective arteriolar vasodilator. Found inside – Page 201Unlike nitroprusside, nitroglycerin poses no risk of cyanide toxicity. For this reason, nitroglycerin may be chosen over nitroprusside to control ... Found inside – Page 666Cyanide toxicity may manifest as metabolic acidosis, dyspnea, confuSion, and headache. Nitroglycerin causes venodilation at low doses and both Veno- and ... Found inside – Page 148Nitroglycerin commonly causes severe headache in these patients and nitroprusside has acute toxic effects due to ... Intraarterial infusion permits lower doses , further lessening the adverse effects of cyanide toxicity ( Dierckx et al , 1986 ) . Found inside – Page 480This mechanism is similar to that of nitroglycerin. ... The chances of cyanide poisoning can be minimized by avoiding prolonged infusion in patients with liver disease and by ... If cyanide toxicity occurs, nitroprusside should be discontinued. Found inside – Page 309Long - term ( > 48 - hour ) infusions of all three drugs is fraught with difficulties ( i.e. , the development of hemodynamic tolerance with nitroglycerin , the risk of cyanide and thiocyanate toxicity with nitroprusside , and renal impairment and ... Found inside – Page 386venodilators , such as nitroglycerin or morphine . ... Thiocyanate and cyanide toxicity may develop from accumulation of toxic metabolites with long - term ... Found inside – Page 208Nitroglycerin Sodium Nitrite and Sodium Thiosulfate Doses for Treatment of Cyanide Poisoning From Nitroprusside Toxicity Initial Dose of 3% Initial Dose of ... Found inside – Page 538Nitroglycerin reduces myocardial oxygen demand and dilates pulmonary vessels , giving it an added advantage . Similar to other ... Side effects of nitroprusside can be related to either cyanide or thiocyanate toxicity . Nitroprusside is ... Found inside – Page 119It is more expensive than nitroglycerin and can cause cyanide toxicity with prolonged infusion and/or higher infusion rates but is also a cornerstone of ... NOTE: NO FURTHER DISCOUNT FOR THIS PRINT PRODUCT- OVERSTOCK SALE -Significantly reduced listprice The official Emergency Response Guidebook (ERG) is a guide for use by transporters, firefighters, police, and other emergency services ... Found inside – Page 303Cyanide toxicity is the major concern with high dose (.8–10 mcg/kg/min) ... Nitroglycerin Nitroglycerin is a venous and arterial dilator with a fast ... Found inside – Page 215Cyanide toxicity is characterized by the unexplained development of metabolic acidosis, ... Nitroglycerin Nitroglycerin has been used to induce controlled ... Found inside – Page 98Its major disadvantage is the potential for cyanide toxicity with prolonged administration of high doses of the drug . Nitroglycerin can also be administered intravenously to induce hypotension . Beta adrenergic blocking agents such as labetolol ... Found inside – Page 377A major mechanism of cyanide toxicity is binding to cytochrome oxidase in the ... has been recommended.357“'357b Nitroglycerin Nitroglycerin is primarily a ... Found inside – Page 277Cyanide toxicity is characterized by an unexplained metabolic acidosis ... Nitroglycerin The main advantages of nitroglycerin are its relatively rapid onset ... Found inside – Page 476Cyanide toxicity is most likely to occur in patients with liver dysfunction ... Nitroglycerin When administered parenterally, nitroglycerin has an immediate ... Found inside – Page 263Signs of cyanide toxicity include mental confusion, tinnitus, ... Nitroglycerin Nitroglycerin (Tridil) causes vasodilation by generating nitric oxide in ... Found insideCoronary Microvascular Obstruction in Acute Myocardial Infarction: From Mechanisms to Treatment provides a comprehensive understanding of the phenomenon of coronary microvascular obstruction (CMVO) that is the main limitation of reperfusion ... Found inside – Page 314Prolonged use can result in cyanide toxicity . sure of 15 to 18 mmHg to optimize left ventricular function . ... Nitroglycerin , morphine , and diuretics are contraindicated in hemodynamically significant right ventricular MI because they decrease ... Found inside – Page 40Cyanide toxicity can occur if the infusion rate is >20 μg/kg/min. Nitroglycerin can reduce afterload and improve coronary artery perfusion, ... Found inside – Page 94concluded that nitroglycerin could be safely and effectively used, avoiding nitroprusside-induced cyanide toxicity, etc. and was therefore the drug of ... Found inside – Page 242One drawback is its potential cyanide toxicity with overdosage. Nitroglycerin (TNG) is a remarkably effective drug for angina pectoris. Nitroprusside is... found inside – Page 386venodilators, such as nitroglycerin or morphine the second edition of Encyclopedia... 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